Þâ²13-glucan Anticancer Efficacies and Synergies a Review

Review

doi: x.3390/nu8090552.

Anticancer Efficacy of Polyphenols and Their Combinations

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• PMID: 27618095
• PMCID: PMC5037537
• DOI: 10.3390/nu8090552

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Review

Anticancer Efficacy of Polyphenols and Their Combinations

Aleksandra Niedzwiecki  et al. Nutrients. 2016 .

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Abstract

Polyphenols, found abundantly in plants, brandish many anticarcinogenic properties including their inhibitory furnishings on cancer cell proliferation, tumor growth, angiogenesis, metastasis, and inflammation as well as inducing apoptosis. In add-on, they tin modulate immune system response and protect normal cells against gratis radicals damage. Well-nigh investigations on anticancer mechanisms of polyphenols were conducted with individual compounds. However, several studies, including ours, take indicated that anti-cancer efficacy and scope of action tin can be farther enhanced by combining them synergistically with chemically similar or different compounds. While most studies investigated the anti-cancer effects of combinations of two or iii compounds, we used more comprehensive mixtures of specific polyphenols and mixtures of polyphenols with vitamins, amino acids and other micronutrients. The mixture containing quercetin, curcumin, green tea, cruciferex, and resveratrol (Atomic number 82) demonstrated pregnant inhibition of the growth of Fanconi anemia head and neck squamous cell carcinoma and dose-dependent inhibition of cell proliferation, matrix metalloproteinase (MMP)-2 and -9 secretion, cell migration and invasion through Matrigel. Lead was found effective in inhibition of fibrosarcoma HT-1080 and melanoma A2058 cell proliferation, MMP-2 and -9 expression, invasion through Matrigel and inducing apoptosis, important parameters for cancer prevention. A combination of polyphenols (quercetin and greenish tea excerpt) with vitamin C, amino acids and other micronutrients (EPQ) demonstrated pregnant suppression of ovarian cancer ES-2 xenograft tumor growth and suppression of ovarian tumor growth and lung metastasis from IP injection of ovarian cancer A-2780 cells. The EPQ mixture without quercetin (NM) also has shown strong anticancer activeness in vivo and in vitro in a few dozen cancer prison cell lines by inhibiting tumor growth and metastasis, MMP-2 and -9 secretion, invasion, angiogenesis, and jail cell growth as well as induction of apoptosis. The presence of vitamin C, amino acids and other micronutrients could enhance inhibitory effect of epigallocatechin gallate (EGCG) on secretion of MMPs. In addition, enrichment of NM with quercetin (EPQ mix) enhanced anticancer activeness of NM in vivo. In conclusion, polyphenols, especially in combination with other polyphenols or micronutrients, have been shown to be effective against multiple targets in cancer development and progression, and should be considered as safety and constructive approaches in cancer prevention and therapy.

Keywords: Matrigel invasion; metastasis; polyphenols; tumor growth.

Disharmonize of involvement statement

The authors declare no conflict of involvement.

Figures

Figure ane

Gross photographs of representative tumors from Control and EPQ groups of mice inoculated with ovarian cancer ES-2 cells. Hateful tumor weight and burden of EPQ group tumors were inhibited past 59.2% (p < 0.0001) and 59.vii% (p < 0.0001) compared to Control grouping, respectively.

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